Restore Healthy Gastrointestinal Integrity with Gut Health!

Gut Health is the latest in probiotic technology. Containing a specialized force of complementary probiotic strains, Gut Health helps contribute to optimized nutrient absorption, protection against foodborne/environmental pathogens, prevention of bowel irritation/inflammation, support for a powerful immune system and reduction of GI stress caused by modern diet.

Got Protein Farts?

Gut Health is especially effective when used in conjunction with a high-protein diet to help ease bloating and discomfort. Better absorption means reduced gas and diarrhea.

Boost your Immunity and Health

Good health starts in the digestive system. The absorption of nutrients, vitamins, and supplements all take place in the GI Tract as well as detoxification and elimination. Gut Health aids in optimizing the overall function, integrity, and health of your digestive system.

Slin Sane

Genomyx' Slin-Sane: Skin Bursting Pumps!

Physique athletes have long since realized the profound benefits of the anabolic hormone insulin, whether it be through maximizing endogenous timing and release or simply by injecting the exogenous compound. Insulin release is stimulated in the body simply by the ingestion of carbohydrates, certain amino acids, or the combination of both. However, many people have inherent dysfunction in the complex insulin signaling cascade, which can result in limited nutrient uptake by the muscle cells, excessive uptake by the fat cells, too much insulin released, or too little insulin released. Even those with proper nutrient signaling can still greatly benefit their quest for increased muscle gain and accelerated fat loss by optimizing the body’s nutrient storage capabilities.

Slin-Sane was designed to be just that nutrient storage optimization tool, by working to maximize uptake of glucose and amino acids at the muscle cell through multiple angles similar to and in conjunction with insulin, while delivering increased vascularity and muscle fullness.

Overview of ingredients and function:

Lagerstroemia Speciosa

A small to medium sized tree grown throughout parts of southern Asia, the leaves of Lagerstroemia Speciosa (LS) yield a novel compound called Banaba. Commonly used in Phillipine folk medicine to treat symptoms of diabetes, this compound shows great promise for its multi-faceted beneficial interaction with glucose and insulin.

Initially, researchers thought banaba’s positive effects to be solely related to its content of corosolic acid, but studies have since shown there may be multiple other compounds in the leaf that contribute to its numerous benefits.

Multiple studies have shown LS to have the ability to increase translocation of the GLUT4 receptor at the muscle cell, therefore allowing increased nutrient uptake (1,9). This cellular receptor is the main gatekeeper for nutrient influx, and optimal expression can greatly enhance cellular storage capabilities, increasing muscle fullness.

A recent study out of Japan found a significant reduction in blood glucose response after feeding sugar to subjects pretreated with LS versus subjects who didn’t take the supplement (2). A similar study published in Diabetes Research and Clinical Practice also showed a potent glucose lowering effect over control from ingestion of 75g of glucose after administration of LS (6). In addition to reduction in glucose response to food intake, LS has been shown in multiple studies to lower fasting glucose and insulin levels, a key marker in overall health and cell responsiveness to nutrient sensing (3,8,10,13).

Aside from Lagerstroemia’s basic glucose stabilizing effects, it touts numerous other capabilities related to health and longevity including elevating insulin sensitivity (8), lowering free fatty acids, blood pressure, CRP, and oxidative stress (7), suppression of adipocyte differentiation similar to AICAR (5), reducing triglycerides and A1C levels (8), and significantly lowering hepatic lipid content (11).

Looking at things purely from a body composition angle, LS can help promote the anabolic effects of insulin by mimicking the hormone and working through an independent mechanism of insulin itself (12), act anti-catabolically to prevent muscle breakdown (4), lower fasting glucose/insulin levels, and increase insulin sensitivity to aid in fat loss and muscle gain.

Lagerstroemia Review

• Enhances glucose uptake at muscle cell
• Reduces fat gain from a high fat diet
• Lowers blood glucose response to feeding
• Reduces fasting glucose, insulin, triglycerides, FFA’s, CRP and A1C
• Increases insulin sensitivity and GLUT4 translocation
• Increases adiponectinGymnema Sylvestre

Gymnema Sylvestre

Used as a natural treatment for diabetic symptoms in parts of India for thousands of years, this tropical herb has many promising attributes for the modern day physique enthusiast. Much of the research on this compound has focused on diabetic conditions, with some pretty incredible results.

Studies have shown Gymnema to reverse elevated cholesterol and triglycerides (15,17,26), decrease serum blood glucose in a fasted and fed state (16,20,22,24,26), and improve the time it takes to clear glucose from the bloodstream post-prandially (24). A long term study out of India looked at diabetics who had been given Gymnema daily for up to a year, and found that fasting glucose levels had dropped from an average of 232 mg/dL to a remarkable 152 mg/dL, with no change in the control group. The Gymnema group was able to halve their required insulin dosages over the course of the study, and they also showed a significant drop in A1C levels (22), which was later confirmed by a 2009 study in the journal Phytomedicine (26).

Gymnema has a profound effect on the insulin secreting cells of the pancreas, known as the beta cells located inside the islets of Langerhans. The herb has the unique ability to stimulate insulin release, even without the presence of carbs (18), and can actually regenerate the beta cells that often become damaged and dysfunctioning over time (22). One study published in the Journal of Ethnopharmacology even found Gymnema to double the number of beta and islet cells in diabetic rats (23).

Aside from the profound effects on pancreatic function, Gymnema also acts at nutrient destination cells by increasing permeability of cell walls, which assists in the process of nutrient uptake (18). Damaged cell walls become less permeable over time, due to excess insulin in the bloodstream and dietary deficiencies, among other things. Gymnema acts as sort of a cellular repair kit, restoring optimal function.

The addition of Gymnema alongside Lagerstroemia to Slin-Sane allows for a two-pronged attack for optimization of glucose and insulin. By increasing the enzymes responsible for glucose utilization (25), enhancing the action of endogenous insulin (22), stimulating insulin release and repairing beta cells, increasing cell permeability and repairing insulin induced damage to the liver, kidney and muscle cells (25), Gymnema will aid in driving nutrients into the muscles for a full, pumped feeling and increased performance.

 Gymnema Review:

• Stimulates insulin release and mimicks insulin
• Increases nutrient uptake
• Increases cell permeability
• Reduces serum glucose, cholesterol, triglycerides, and A1C
• Elevates HDL levels
• Regenerates pancreatic cells

L-Norvaline

An analogue of the branched chain amino acid L-Valine, this compound was chosen due to its vasodilating properties for an increase vascularity, muscle pump, and nutrient delivery.

L-Norvaline works by inhibiting the arginase enzyme, which is responsible for the breakdown of L-Arginine into L-Ornithine and urea (28-30). An animal study published in the American Journal of Heart and Circulatory Physiology found that L-Norvaline increased Nitric Oxide production by 55% (28).

L-Norvaline Review:

• Increases Nitric Oxide production
• Causes vasodilation and muscle pump

Slin-Sane Overview:

• Enhances vasodilation and muscle pumps
• Elevates nitric oxide
• Drives nutrients into cells
• Stimulates insulin release, mimicks insulin and enhances insulin’s endogenous effect
• Reduces fasting glucose and insulin
• Reduces glucose response to meals
• Reduces fat gain and speeds up fat loss
• Regenerates pancreatic beta cells
• Supports healthy blood lipids
• Lowers liver lipid content (major factor in cardiovascular disease)
• Increases plasma adiponectin

Damage Control Protocol!

Ingredients Profile:

• TTA
• Salvia Miltiorrhiza
• Propionyl-L-Carnitine
• Potassium Pyruvate
• Raspberry Ketones

DCP is an effective combination of TetradecylThioacetic Acid (250mg), Salvia Miltiorrhiza Extract (standardized for 40% Mixed Tanshinones) (250mg), Propionyl-L-Carnitine (300mg), Potassium Pyruvate (300mg), and Raspberry Ketones (100mg). You may have seen some of these ingredients in other products, but lets look at why we chose them specifically to work in concert to help you become the lean, mean, muscle building machine you want to be.

The center ingredient in which our product is based off of is of TetradecylThioacetic Acid (TTA). TTA is a 3-thia fatty acid which increases mitochondrial activity, which in itself provides numerous benefits. Insulin resistance is strongly linked to the reduction of glucose oxidation in mitochondria and a subsequent build up of glycolysis byproducts. Adipocytes also contribute hormones when fat is stored in them, so, the more fat you are carrying, the more inhibition of mitochondrial function you have (1). Mitochondria proteins function mainly to produce ATP, enhancing their function will, in short, burn more fuel. TTA enhances mitochondrial oxidative capacity and reduces free fatty acid and triglyceride levels as described below. 

The peroxisome proliferator-activated receptors (PPARs) are transcription factors regulated by fatty acid derivatives, among others. These receptors are intimately involved in glucose regulation, cellular proliferation and differentiation, and most important to us, fat metabolism. There are at present three types of PPARs: alpha, gamma, and delta. The liver is the main site where fatty acids are stored or burned for energy, depending on calorie intake. When fasting, fuel sources switch from carbohydrates and fats to mainly fats, and fatty acids are released from adipocytes. In the liver, they are either reesterified to triglycerides and form very low-density lipoproteins (VLDL), which then go on to restore in adipocytes or go to cardiac and skeletal muscle for energy. They can also be broken down through beta-oxidation to form ketones. PPAR-alpha mediates the genes controlling fatty acid uptake, beta-oxidation, and gamma-oxidation, which are upregulated when in a fasted state. TTA is a PPARalpha agonist, meaning it activates these receptors. Thus, you experience the same benefits even if you are in a fed state (9,15-18). PPAR-alpha also down-regulates apolipoprotein C-III which inhibits triglyceride hydrolysis, further enhancing lipid oxidation (2). 

TTA also increases the activity of enzymes of the carnitine palmitoyltransferase (CPT) sytem (9), which shuttles the newly freed up fatty acids into mitochondria to be burned for fuel (10). This system is highly underestimated in a fat loss quest, and it's activity is depressed with increased fat. Propionyl-LCarnitine (PLCAR) was added to further stimulate the CPT system (11), and is converted into propionylcoenzyme A and free carnitine (12). PLCAR has also been suspected to scavenge free radicals, as well as protect DNA from UV damage (12). 

Pyruvate is involved in another complex system called the Pyruvate Dehydrogenase Complex (PDC), which interacts with the CPT system (13). Pyruvate is a Krebs Cycle intermediate, which is rate controlled by the amount of acetyl-CoA that enters the cycle, one of the conversions from pyruvate (13). For simplicity's sake, the result is an ATP/energy enhancement from the mitochondria and an increase in fuel consumption. The electrolyte potassium form was added to attenuate cramping issues observed from previous TTA products. 

Raspberry Ketones (RK) add the finishing touch to DCP. RK is similar in structure to capsaicin and synephrine, and also has been shown to modulate fat metabolism. RK stimulates the release of norepinephrine (NE), a catecholamine with many functions. Most importantly to us is its role in the sympathetic nervous system. NE, having a great affinity on beta and alpha-1 adrenoreceptors in the body, activates lipolysis that normally only occurs during exercise or other intensive activity. This results in an increase of free fatty acids which will be burned via methods described above (14). 

As you can see, DCP attacks fat from many angles. It can be especially effective when bulking to prevent fat storage and also has appetite suppressive properties in some users, or used in a cut to potentiate the body's fasting enzymatic response.